Twinaqt Tablet
₹ 2,099.00/-
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Composition:
- Dolutegravir (50mg)
- Lamivudine (300mg)
Product Description: Twinaqt Tablet is a combination of two antiretroviral medications, Dolutegravir and Lamivudine, prescribed for the treatment of HIV (Human Immunodeficiency Virus) infection. This medicine works by boosting the immune system to manage and treat HIV/AIDS, reducing the risk of complications, and improving overall lifespan. It helps prevent the growth of the HIV virus within the body.
Twinaqt Tablet can be taken with or without food. It is crucial to take the medicine at the same time daily and not miss any doses, as missing doses can affect the treatment's effectiveness. Always complete the prescribed course of treatment unless your doctor advises otherwise. Discontinuing the medicine suddenly may reduce its efficacy.
Common side effects may include headache, nasal congestion, diarrhea, nausea, weakness, tiredness, cough, and rash. These side effects are generally temporary, but if they persist or worsen, consult your doctor. Drink plenty of fluids to stay hydrated and help manage these side effects.
Dosage and Administration:
- Take the tablet as prescribed by your doctor, either with or without food.
- Swallow the tablet whole with water. Do not chew, crush, or break it.
- Follow the dosage instructions carefully to ensure optimal effectiveness.
Side Effects:
Common Side Effects:
- Headache
- Fever
- Abdominal pain
- Weakness
- Diarrhea
- Nausea
- Vomiting
- Joint pain
- Insomnia
- Gastrointestinal disturbances
- Dizziness
- Anxiety
- Itching
- Rash
- Fatigue
- Hair loss
- Muscle pain
- Decreased phosphate levels in blood
- Increased transaminase levels in blood
Serious Side Effects:
- Severe allergic reactions (fever, rash, difficulty breathing, swelling of face or mouth)
- Extreme tiredness or weakness
- Unusual or persistent symptoms should be reported to your healthcare provider.
Therapeutic Effects:
Twinaqt Tablet inhibits enzymes necessary for HIV replication:
- Dolutegravir blocks the integrase enzyme, preventing the insertion of viral DNA into the DNA of immune cells.
- Lamivudine inhibits the reverse transcriptase enzyme, which is crucial for converting viral RNA into DNA.
Interactions with Other Drugs:
Twinaqt Tablet may interact with other medications, including prescription drugs, over-the-counter medications, and herbal supplements. Inform your doctor about all the medications you are currently taking to avoid possible drug interactions that can affect the drug's efficacy or cause side effects.
Avoid taking antacids within 6 hours before or 2 hours after this medicine, as they can interfere with absorption. Other acid-lowering medications, such as ranitidine or omeprazole, can be taken with this tablet.
Precautions:
- Pregnancy: Twinaqt Tablet may increase the risk of malformations in the baby if taken in the early stages of pregnancy. Discuss potential risks with your doctor if you are pregnant, planning to get pregnant, or suspecting pregnancy.
- Breastfeeding: Not recommended, as HIV can be transmitted through breast milk.
- Liver Issues: Inform your doctor if you have any history of liver problems, including hepatitis B or C, as they may reactivate.
- Alcohol: It is unclear whether alcohol interacts with Twinaqt Tablet, so it’s advisable to discuss with your doctor if you consume alcohol.
- Driving: This tablet may cause dizziness, so avoid driving if you feel unwell.
FAQs
Can Twinaqt Tablet be used with other drugs?
Yes, Twinaqt Tablet is often used in combination with other antiretroviral drugs to maximize effectiveness and minimize resistance.
How does Twinaqt Tablet work?
It inhibits two essential enzymes involved in the replication of HIV: integrase and reverse transcriptase.
Is Twinaqt Tablet safe for breastfeeding?
No, it should not be used during breastfeeding due to the risk of transmitting HIV to the infant through breast milk.
Who should avoid Twinaqt Tablet?
Individuals with a known allergy to any ingredient in the tablet should avoid using it.
Additional Information:
- Storage: Store at room temperature (30°C), away from moisture, heat, and direct light.
- Keep out of the reach of children.
Fact Box:
- Molecule Name: Dolutegravir, Lamivudine
- Therapeutic Class: Antiretrovirals
- Pharmacological Class:
- Dolutegravir – Integrase inhibitors (INIs)
- Lamivudine – Nucleoside reverse transcriptase inhibitors (NRTIs)
- Indications: Human Immunodeficiency Virus (HIV)
References:
- ViiV Healthcare UK Limited, Electronic Medicines Compendium (EMC), Revised May 2021
- Kandel CE, Walmsley SL, Dolutegravir – a review of the pharmacology, efficacy, and safety with the treatment of HIV, Drug Des Devel Ther., 2015, 7(9), 3547-55, Link
- KD Tripathi, Essentials of Medical Pharmacology, Antiviral Drugs, 7th Edition, 2013, 807-808.
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Antiretroviral Agents and Treatment of HIV Infection, 12th Edition, 2011, 1634-1635.
