Trilavir Mini Tablets
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About Trilavir Mini Tablet
Salt Composition:
- Lamivudine (300mg)
- Tenofovir disoproxil fumarate (300mg)
- Efavirenz (400mg)
- Trilavir Mini Tablet is a combination of three antiretroviral medicines. It is primarily prescribed to treat HIV (human immunodeficiency virus) infection and boosts the immunity to help manage or treat AIDS (acquired immunodeficiency syndrome).
This medication works by restricting the growth of the HIV virus in the body, reducing the risk of HIV-related complications, and improving the individual's lifespan. For optimal efficacy, it should be taken on an empty stomach, preferably at bedtime. To ensure the effectiveness of the medication, it’s important to take it regularly and at the same time each day. Missing a dose can affect the treatment process, so never skip a dose without consulting your doctor.
Common Side Effects:
- Impaired concentration
- Abnormal dreams
- Headache
- Nausea
- Weakness and fatigue
- Nasal congestion
- Diarrhea
- Rash
- Dizziness
- Trouble sleeping
- Pain
- Depression
- Cough
These side effects are generally mild and may subside after 2-4 weeks of treatment. However, if these symptoms persist or become bothersome, it’s advisable to consult your doctor. Since this medication can cause dizziness or drowsiness, avoid driving while on this medication. It is also recommended to refrain from alcohol consumption as it can intensify side effects.
Uses of Trilavir Mini Tablet
HIV Infection
Trilavir Mini Tablet prevents the multiplication of the HIV virus, which helps control the infection and enhances the functioning of the immune system. This significantly lowers the chances of complications like new infections and improves overall quality of life. However, it is important to note that Trilavir Mini Tablet is not a cure for HIV or AIDS, nor should it be used as a preventive measure for HIV after accidental exposure to risk.
Side Effects of Trilavir Mini Tablet
Serious Side Effects:
- Rapid breathing
- Drowsiness
- Nausea, vomiting, and stomach pain
- Severe allergic reactions
- Mood disturbances, depression, and suicidal thoughts
- Confusion, forgetfulness, seizures, and tremors
- Liver toxicity
- Kidney damage
- Autoimmune disorders
Common Side Effects:
- Bloating and flatulence
- Headache
- Sleeplessness
- Skin reactions
- Wheezing, swelling, or lightheadedness
- Hair loss
- Diarrhea
- Bone disorders
- Weakness
- Anemia
Most side effects are not serious and may disappear as the body adjusts to the medication. If any of these persist or cause concern, please inform your doctor.
How to Use Trilavir Mini Tablet
Take the tablet as prescribed by your doctor. Do not chew, crush, or break the tablet; swallow it whole. For best results, take Trilavir Mini Tablet on an empty stomach.
How Trilavir Mini Tablet Works
Trilavir Mini Tablet is a combination of three antiviral medicines:
- Lamivudine (a nucleoside reverse transcriptase inhibitor or NRTI)
- Tenofovir disoproxil fumarate (another NRTI)
- Efavirenz (a non-nucleoside reverse transcriptase inhibitor or NNRTI)
These medicines work together to stop the HIV virus from multiplying and reduce the amount of virus in the body. They also help increase the CD4 cell count (white blood cells that protect against infection), thus enhancing the immune system.
Safety Advice
Pregnancy:
Trilavir Mini Tablet is unsafe during pregnancy due to potential risks to the developing baby. However, in life-threatening situations, a doctor may prescribe it if the benefits outweigh the risks. Always consult your doctor for advice.
Breastfeeding:
Trilavir Mini Tablet is likely safe during breastfeeding, as limited human data suggest that it does not pose significant risk to the baby.
Kidney & Liver:
Trilavir Mini Tablet can be used in patients with kidney or liver disease, but your doctor may adjust the dose based on your health condition. Regular monitoring may be necessary.
Alcohol:
Exercise caution when consuming alcohol with Trilavir Mini Tablet, as alcohol can increase the intensity of side effects.
Driving:
Trilavir Mini Tablet may cause dizziness, sleepiness, or blurred vision. Do not drive or engage in activities requiring focus until you understand how the medication affects you.
What if You Miss a Dose?
If you miss a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take double doses to make up for a missed dose.
Quick Tips
- Trilavir Mini Tablet is a combination of three medicines that slow down or stop the progression of HIV infections.
- Take it on an empty stomach, preferably before bedtime, to minimize side effects.
- Skipping doses can increase the risk of treatment failure. Ensure timely intake of the medicine as prescribed.
- It can cause dizziness or sleepiness. Avoid driving or operating heavy machinery until you know how it affects you.
- Use effective contraception while taking Trilavir Mini Tablet and for 12 weeks after stopping the medication, as it may cause birth defects.
- Exercise regularly and take calcium and vitamin D supplements to help prevent bone weakening, as advised by your doctor.
- Regularly monitor your kidney and liver functions. Consult your doctor if you notice symptoms like abdominal pain, loss of appetite, dark urine, or yellowing of the eyes or skin.
- Do not stop taking Trilavir Mini Tablet without consulting your doctor.
FAQs
Q1. What should you not take with Trilavir Mini Tablet?
Avoid taking other HIV medications along with Trilavir Mini Tablet unless prescribed by your healthcare provider. Inform your doctor about all medicines you're taking, including over-the-counter drugs, vitamins, and herbal supplements.
Q2. How can Trilavir Mini Tablets be stored?
Store Trilavir Mini Tablets below 30°C, in its original container, and out of reach of children.
Q3. What should you do if you miss a dose?
If you miss a dose, take it as soon as possible unless it’s almost time for your next dose. In that case, skip the missed dose. Never take two doses to compensate for the missed one.
Q4. What laboratory tests are required before starting Trilavir Mini Tablet?
Laboratory tests like pregnancy tests, HBV infection tests, serum creatinine, and creatinine clearance are required before starting the treatment.
Q5. How can you know if you're hypersensitive to Trilavir Mini Tablet?
Signs of hypersensitivity may include severe rash, swelling of the face or lips, or symptoms of Steven’s Johnson Syndrome. If you experience any of these, contact your doctor immediately.
Fact Box
- Molecule Name: Efavirenz, Lamivudine, Tenofovir disoproxil fumarate
- Therapeutic Class: Antiretroviral
- Pharmacological Class:
- Nucleoside reverse transcriptase inhibitors (NRTIs)
- Non-nucleoside reverse transcriptase inhibitors (NNRTIs)
- Indication: Human Immunodeficiency Virus (HIV-1) infection
References:
- Macleods Pharmaceuticals Limited
- US Food and Drug Administration
- KD Tripathi, Antiviral Drugs (Anti-retrovirus), Essentials of Medical Pharmacology, 8th Edition, 2019